Table 1.
Baseline clinical, pathological, surgical, and outcome characteristics according to BRCA variant classification
| Characteristic | Pathogenic BRCA (n: 107) |
BRCA VUS (n: 96) |
p value |
|---|---|---|---|
| Age at diagnosis, median(IQR) | 44 (39–50) | 49 (42–58) | < 0.001 |
| Tumor sidedness | 0.57 | ||
| Left | 49/105 (46.7%) | 47/94 (50%) | |
| Right | 51/105 (48.6%) | 45/94 (47.9%) | |
| Bilateral | 5/105(4.8%) | 2/94 (2.1%) | |
| Initial clinical approach | 0.35 | ||
| Upfront surgery | 44/106 (41.5%) | 47/94 (50%) | |
| Neoadjuvant therapy | 56/106 (52.8%) | 41/94 (43.6%) | |
| Other systemic approach | 6/106 (5.7%) | 6/94 (6.4%) | |
| Initial tumor size, mm | 24 (17–32)* | 25 (15–30)* | 0.78 |
| Tumor grade | 0.21 | ||
| Grade 1 | 5 (5%) | 8 (10%) | |
| Grade 2 | 33 (36%) | 32 (42.7%) | |
| Grade 3 | 54 (58%) | 35 (46.7%) | |
| Ki-67, % | 40 (20–70) | 30 (15–50) | 0.019 |
| Molecular subtype | 0.001 | ||
| Luminal A | 10 (9.7%) | 18 (20.5%) | |
| Luminal B | 42 (40.8%) | 36 (40.9%) | |
| HER2 | 14 (13.6%) | 22 (25.0%) | |
| Triple-negative | 37 (35.9%) | 12 (13.6%) | |
| Family history of cancer | < 0.001 | ||
| First degree relative breast cancer | 33 (32.7%) | 12 (12.6%) | |
| First degree relative ovarian cancer | 9 (8.9%) | 4 (4.2%) | |
| First degree relative pancreatic cancer | 1 (1%) | 0 (0%) | |
| Second degree relative breast cancer | 26 (25.7%) | 21 (22.1%) | |
| No family history | 32 (31.7%) | 58 (61.1%) | |
| Type of initial breast surgery | 0.016 | ||
| Mastectomy | 65 (65%) | 39 (44%) | |
| Breast-conserving surgery | 35 (35%) | 49 (56%) | |
| Completion mastectomy | < 0.001 | ||
| Yes | 26 (26%) | 4 (5%) | |
| No | 74 (74%) | 84 (95%) | |
| Final bilateral mastectomy | < 0.001 | ||
| Yes | 67 (67%) | 11 (12%) | |
| No | 33 (33%) | 77 (88%) | |
| Prophylactic oophorectomy | < 0.001 | ||
| Performed | 39(57.4%) | 7(17.5%) | |
| Not performed | 29 (42.6%) | 33(82.5%) | |
| Recurrence | 0.62 | ||
| Present | 12/92 (13%) | 8/84 (10%) | |
| Absent | 80/92 (87%) | 76/84 (90%) | |
| Vital status | 0.69 | ||
| Alive | 78/86 (91%) | 73/78 (94%) | |
| Deceased | 8/86 (9%) | 5/78 (6%) |
Data are presented as median (interquartile range) for continuous variables and number (%) for categorical variables. Mann–Whitney U test was used for continuous variables (non-normal distributions). Chi-square test or Fisher’s exact test was used for categorical variables, as appropriate. Percentages are calculated based on available cases. Missing data were present for some variables; therefore denominators differ across rows. Bold values indicate statistically significant results (p < 0.05)