Table 3.
Multivariable logistic regression analysis of factors associated with final bilateral mastectomy
| Variable | Adjusted OR (Exp[B]) | 95% CI | p value |
|---|---|---|---|
| BRCA variant category | |||
| Pathogenic vs. VUS | 10.38 | 3.98–27.10 | < 0.001 |
| Age at diagnosis (per year) | 1.047 | 1.008–1.088 | 0.019 |
| Molecular subtype (overall) | — | — | 0.834 |
| Luminal B vs. Luminal A | 1.784 | 0.258–12.343 | 0.557 |
| HER2 + vs. Luminal A | 1.523 | 0.485–4.787 | 0.471 |
| Triple-negative vs. Luminal A | 0.989 | 0.259–3.769 | 0.987 |
| Ki-67 (per 1% increase) | 1.005 | 0.983–1.027 | 0.679 |
| Tumor grade (overall) | — | — | 0.912 |
| Grade 2 vs. Grade 1 | 1.590 | 0.175–14.402 | 0.680 |
| Grade 3 vs. Grade 1 | 1.032 | 0.359–2.969 | 0.953 |
| Family history of cancer (yes vs. no) | 1.190 | 0.492–2.877 | 0.699 |
Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained from multivariable logistic regression analysis. Molecular subtype was entered as a categorical variable with Luminal A as the reference category. Age and Ki-67 were entered as continuous variables. Tumor grade was entered as an ordinal variable. The reference category for BRCA variant status was VUS. Abbreviations OR odds ratio, CI confidence interval, VUS variants of uncertain significance, BRCA breast cancer susceptibility gene. Bold values indicate statistically significant results (p < 0.05)