Table 4.
Clinicopathological factors according to final surgery type among BRCA VUS carriers (n = 96)
| Variable | Bilateral surgery n (%) or median (IQR) | Non-bilateral surgery n (%) or median (IQR) | p value |
|---|---|---|---|
| Molecular subtype | 0.718 | ||
| Luminal A | 1/18 (5.6%) | 17/18 (94.4%) | |
| Luminal B | 2/36 (5.6%) | 34/36 (94.4%) | |
| HER2+ | 2/22 (9.1%) | 20/22 (90.9%) | |
| Triple-negative | 2/12 (16.7%) | 10/12 (83.3%) | |
| Subtype (collapsed) | 0.206 | ||
| Luminal | 3/55 (5.5%) | 52/55 (94.5%) | |
| Non-luminal | 4/33 (12.1%) | 29/33 (87.9%) | |
| Family history of cancer | 0.817 | ||
| Absent | 5/58 (8.6%) | 53/58 (91.4%) | |
| Present | 2/37 (5.4%) | 35/37 (94.6%) | |
| BRCA VUS gene | 0.343 | ||
| BRCA1 | 4/32 (12.5%) | 28/32 (87.5%) | |
| BRCA2 | 4/64 (6.3%) | 60/64 (93.8%) | |
| Age at diagnosis, years | 43 (41–49) | 49 (41–59) | 0.043 |
| Ki-67, % | 30 (15–50) | 30 (15–50) | 0.338 |
| Initial tumor size, mm | 25 (15–30) | 25 (15–30) | 0.981 |
Data are presented as number (%) for categorical variables and median (interquartile range) for continuous variables. P values for categorical variables were calculated using Pearson’s chi-square test, and P values for continuous variables were calculated using the Mann–Whitney U test. Due to small cell counts in several comparisons, results should be interpreted cautiously. Analyses were performed as exploratory univariate screening among BRCA VUS carriers. Abbreviations VUS variants of uncertain significance, IQR interquartile range. Bold values indicate statistically significant results (p < 0.05)