Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Role of cytokines in protection and pathology (mice)
| Cytokine | Statusa
|
||
|---|---|---|---|
| Parasitemia | Anemia | CM | |
| IL-12 | ↓ | ↓ | ↑ |
| IFN-γ | ↓ | = | ↑ |
| TNF-α | ↑ | = | ↑ |
| IL-10 | =, ↓ (late phase) | = | =, ↓ |
| IL-4 | =, ↓ (late phase) | =, ↓ | |
| TGF-β | ↑, ↓ | ↓ | |
| IL-1 | ↓ | = | ↑? |
| IL-6 | = | = | = |
| IL-18 | ↑ | ||
| MIF | - | ↑? | |
Inferred role of the cytokines, derived from data from cytokine administration, neutralization with antibodies or clinical correlations (see text for details). =, No effect; ↑, increase; ↓, decrease; ?, to be confirmed.
