Table 2.

Distribution of risk gene variants studied in RCC (N = 168) cases and healthy controls (N = 259).

SNPs	Genetic model	HC N (%)	RCC patient N (%)	p-value
rs1049380 (ITPR2)	Codominant
	T/T	150 (58.6)	95 (56.5)	0.220
	G/T	85 (33.2)	65 (38.7)
	G/G	21 (8.2)	8 (4.8)
	Dominant
	T/T	150 (58.6)	95 (56.5)	0.690
	G/T + G/G	106 (41.4)	73 (43.5)
	Recessive
	T/T + G/T	235 (91.8)	160 (95.2)	0.140
	G/G	21 (8.2)	8 (4.8)
rs10771279 (ITPR2)	Codominant
	T/T	81 (31.5)	66 (39.3)	0.018
	C/T	126 (49)	85 (50.6)
	C/C	50 (19.5)	17 (10.1)
	Dominant
	T/T	81 (31.5)	66 (39.3)	0.097
	C/T + C/C	176 (68.5)	102 (60.7)
	Recessive
	T/T + C/T	207 (80.5)	151 (89.9)	0.007
	C/C	50 (19.5)	17 (10.1)
rs4903064 (DPF3)	Codominant
	T/T	137 (53.5)	73 (43.7)	0.036
	C/T	105 (41)	75 (44.9)
	C/C	14 (5.5)	19 (11.4)
	Dominant
	T/T	137 (53.5)	73 (43.7)	0.048
	C/T + C/C	119 (46.5)	94 (56.3)
	Recessive
	T/T + C/T	242 (94.5)	148 (88.6)	0.030
	C/C	14 (5.5)	19 (11.4)
rs7579899 (EPAS1)	Codominant
	G/G	117 (45.5)	64 (38.1)	0.073
	A/G	108 (42)	70 (41.7)
	A/A	32 (12.4)	34 (20.2)
	Dominant
	G/G	117 (45.5)	64 (38.1)	0.120
	A/G + A/A	140 (54.5)	104 (61.9)
	Recessive
	G/G + A/G	225 (87.5)	134 (79.8)	0.032
	A/A	32 (12.4)	34 (20.2)
rs35252396 (PVT1)	Codominant
	AC/AC	83 (32)	45 (26.8)	0.480
	AC/CG	121 (46.7)	83 (49.4)
	CG/CG	55 (21.2)	40 (23.8)
	Dominant
	AC/AC	83 (32)	45 (26.8)	0.240
	AC/CG + CG/CG	176 (68)	23 (73.2)
	Recessive
	AC/AC + AC/CG	204 (78.8)	128 (76.2)	0.481
	CG/CG	55 (21.2)	40 (23.8)

p-values <0.05 are shown in italics. p-values <0.01 (Bonferroni-corrected significance) are shown in bold.