Table 4.
Association between allelic combinations and response, adjusted for age and sex.
| rs10771279 (ITPR2) | rs4903064 (DPF3) | rs7579899 (EPAS1) | HC (frequency, %) | RCC (frequency, %) | OR (95% CI) | p-value |
|---|---|---|---|---|---|---|
| T | T | G | 26.26 | 24.51 | 1.00 | — |
| C | T | G | 22.18 | 13.32 | 0.62 (0.34–1.16) | 0.13 |
| T | T | A | 14.44 | 17.22 | 1.23 (0.67–2.24) | 0.51 |
| T | C | G | 11.28 | 13.67 | 1.47 (0.74–2.93) | 0.27 |
| C | T | A | 11.14 | 11.11 | 1.14 (0.62–2.08) | 0.67 |
| C | C | G | 6.81 | 7.43 | 1.06 (0.48–2.32) | 0.89 |
| T | C | A | 4.04 | 9.19 | 2.28 (1.06–4.90) | 0.035 |
| C | C | A | 3.84 | 3.56 | 0.98 (0.33–2.88) | 0.96 |
p-values <0.05 are shown in italics. None of the associations remained statistically significant after Bonferroni correction (corrected threshold: p < 0.0071).