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[Preprint]. 2026 Mar 18:2026.02.21.707172. [Version 3] doi: 10.64898/2026.02.21.707172

Figure 2. Reln haploinsufficiency does not alter fentanyl dose-response or motivation during intravenous self-administration.

Figure 2.

A-B Active (solid line) and inactive (dashed line) lever presses (A) or fentanyl infusions (B) across the dose-response phase, in which the unit dose was decreased sequentially from 15 to 10, 5, and 1.5 μg/kg/infusion over IVSA Days 5–12, followed by a dose reset to 15 μg/kg/infusion (Day 13–14; dotted vertical line). Data are mean ± SEM. (C-D) Total active and inactive lever presses (C) and breakpoint (D) during the progressive ratio session, in which the response requirement increased with each successive infusion. Data are mean ± SEM. WT, n = 13; Reln+/−, n = 13.