Figure 3. Reln haploinsufficiency does not alter extinction, cue-induced reinstatement, and dorsal striatal immediate early gene expression following reinstatement.

(A) Active (solid line) and inactive (dashed line) lever presses across 10 daily extinction sessions for WT (black) and Reln+/− (blue) mice. (B) Comparison of active and inactive lever presses during the final 30 minutes of the last extinction session (Ext.) and during the subsequent 30-minute cue-induced reinstatement session (Rnst.). (C) Relative expression of immediate early genes Fos, Arc, Egr1, and Npas4 in the dorsal striatum following cue-induced reinstatement, normalized to Gapdh, in WT and Reln+/− mice. Data are mean ± SEM. WT, n = 13; Reln+/−, n = 13.