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. 2005 Nov 30;33(21):6816–6822. doi: 10.1093/nar/gki988

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© The Author 2005. Published by Oxford University Press. All rights reserved

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AT skews obtained from the real genome of Nostoc sp. (black) and artificial ones produced through simulations assuming existence of a single (at 3.2 bp, red), two (at 0 and 3.2 Mb, orange) and three (at 0, 1.6 and 3.2 Mb, blue) distinct replication origins. A clear-cut pattern emerges for the simulated genome with a single replication origin, while for the two- and three-origin models the patterns resemble much the one of the real genome. All three simulations have reached the asymptotic limit (no significant changes are observed for higher number of iterations).