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. 2005 Dec 2;33(21):6906–6919. doi: 10.1093/nar/gki996

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© The Author 2005. Published by Oxford University Press. All rights reserved

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RAD51-3 or RAD51-5 mutation leads to DNA damage sensitivity. The survival of wild-type (WT) T.brucei in the presence of increasing concentrations of MMS was compared with heterozygous (+/−) and homozygous (−/−) mutants of both RAD51-3 and RAD51-5 by plating each cell line at one cell well⁻¹ in 96-well plates. The average number of wells containing growing parasite populations after 7–20 days is plotted as a percentage compared with the average number of wells surviving in the absence of MMS. SD is indicated and the data are presented for two (1 and 2) independent heterozygous and homozygous mutants for each gene.