Table 1 (Abstract O38).

Antibiotic treatment regimen

	Culture Positive	Culture Negative
		mNGS Positive	mNGS Negative
Intravenous preoperative	Pathogen-sensitive antibiotics	Vancomycin 1 g	Vancomycin 1 g
Topical intraoperative	Vancomycin 0.5 g		Vancomycin 0.5 g
*Topical infusion postoperative	Anaerobic bacteria: Vancomycin 0.5 g Gram-positive organisms: Vancomycin 0.5 g Gram-negative organisms: Vancomycin 0.5 g in the morning and carbapenem 0.5 g in the afternoon		Vancomycin 0.5 g in the morning and carbapenem 0.5 g in the afternoon
Intravenous postoperative	Pathogen-sensitive antibiotics for 14 d	Vancomycin 1 g every 12 h for 14 d
Oral postoperative	Quinolones and Rifampicin as an oral switch therapy was adopted for at least 6w until CRP and ESR returned to normal levels

CRP C-reactive protein, ESR erythrocyte sedimentation rate

*Topical infusion antibiotic postoperative for 5–7 days after DAIR and for 14 days after one-stage exchange surgery