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. 2026 Mar 2;25:97. doi: 10.1186/s12933-026-03108-0

Table 2.

Associations between various biomarkers and all-cause death

Unadjusted model HR (95%CI) P Adjusted model HR (95%CI) P
TyG 1.10(0.99–1.23) 0.096 1.14(1.00–1.34) 0.047
 TyG ≤ 8.40 1(Ref.) 1(Ref.)
 TyG > 8.40 1.05(1.01–1.23) 0.034 1.04(1.00–1.27) 0.029
TyG-hsCRP 1.01(1.01–1.02) 0.001 1.01(1.00–1.02) 0.002
 TyG-hsCRP ≤ 11.48 1(Ref.) 1(Ref.)
 TyG-hsCRP > 11.48 1.17(1.01–1.35) 0.035 1.18(1.02–1.39) 0.030
TyG-CRP 1.12(1.07–1.17) 0.001 1.17(1.12–1.22)  < 0.001
 TyG-CRP ≤ 9.40 1(Ref.) 1(Ref.)
 TyG-CRP > 9.40 1.17(1.01–1.35) 0.034 1.31(1.09–1.57) 0.004
CTI 1.16(1.07–1.26)  < 0.001 1.43(1.24–1.65)  < 0.001
 CTI ≤ 8.45 1(Ref.) 1(Ref.)
 CTI > 8.45 1.21(1.05–1.40) 0.008 1.44(1.20–1.74)  < 0.001

Adjusted model was fully adjusted for age, gender, BMI, systolic blood pressure, smoking status, diabetes status, hypertension, dyslipidemia, hemoglobin A1c, estimated glomerular filtration rate, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, use of antidiabetic agents, antihypertensive medication and lipid-lowering medication

TyG Triglyceride-glucose index, hsCRP High-sensitivity C-reactive protein, CRP C-reactive protein, CTI C-reactive protein–triglyceride glucose index, HR Hazard ratio, CI Confidence interval