Table 3.
Associations between various biomarkers and all-cause death across different glycemic statuses
| Unadjusted model HR (95%CI) | P | Adjusted model HR (95%CI) | P | |
|---|---|---|---|---|
| Normoglycemia | ||||
| TyG | 1.09(0.85–1.39) | 0.496 | 1.04(0.64–2.09) | 0.966 |
| TyG ≤ 8.40 | 1(Ref.) | 1(Ref.) | ||
| TyG > 8.40 | 1.09(0.85–1.41) | 0.508 | 1.20(0.80–1.80) | 0.379 |
| TyG-hsCRP | 1.01(1.00–1.02) | 0.026 | 1.01(1.00–1.02) | 0.049 |
| TyG-hsCRP ≤ 11.48 | 1(Ref.) | 1(Ref.) | ||
| TyG-hsCRP > 11.48 | 1.09(0.87–1.35) | 0.469 | 1.06(0.84–1.34) | 0.603 |
| TyG-CRP | 1.07(1.01–1.19) | 0.033 | 1.14(1.06–1.23) | 0.001 |
| TyG-CRP ≤ 9.40 | 1(Ref.) | 1(Ref.) | ||
| TyG-CRP > 9.40 | 1.06(0.84–1.31) | 0.625 | 1.15(1.02–1.32) | 0.03 |
| CTI | 1.13(1.04–1.34) | 0.024 | 1.50(1.16–1.94) | 0.002 |
| CTI ≤ 8.45 | 1(Ref.) | 1(Ref.) | ||
| CTI > 8.45 | 1.28(1.00–1.64) | 0.047 | 1.92(1.38–2.68) | 0.001 |
| Prediabetes | ||||
| TyG | 1.00(0.96–1.05) | 0.474 | 1.00(0.99–1.05) | 0.833 |
| TyG ≤ 8.40 | 1(Ref.) | 1(Ref.) | ||
| TyG > 8.40 | 1.01(0.65–1.29) | 0.601 | 1.03(0.96–1.09) | 0.158 |
| TyG-hsCRP | 1.02(1.00–1.03) | 0.05 | 1.02(1.00–1.03) | 0.042 |
| TyG-hsCRP ≤ 11.48 | 1(Ref.) | 1(Ref.) | ||
| TyG-hsCRP > 11.48 | 1.24(0.88–1.75) | 0.218 | 1.18(1.02–1.42) | 0.013 |
| TyG-CRP | 1.30(1.15–1.47) | 0.001 | 1.28(1.14–1.44) | 0.001 |
| TyG-CRP ≤ 9.40 | 1(Ref.) | 1(Ref.) | ||
| TyG-CRP > 9.40 | 1.13(0.80–1.60) | 0.483 | 1.28(0.84–1.97) | 0.252 |
| CTI | 1.27(1.00–1.63) | 0.045 | 1.70(1.19–2.42) | 0.003 |
| CTI ≤ 8.45 | 1(Ref.) | 1(Ref.) | ||
| CTI > 8.45 | 1.29(1.01–1.83) | 0.014 | 1.73(1.14–2.62) | 0.001 |
| Diabetes | ||||
| TyG | 1.05(0.91–1.23) | 0.459 | 1.04(0.73–1.13) | 0.318 |
| TyG ≤ 8.40 | 1(Ref.) | 1(Ref.) | ||
| TyG > 8.40 | 1.02(0.77–1.21) | 0.787 | 1.01(0.57–1.19) | 0.454 |
| TyG-hsCRP | 1.02(1.00–1.04) | 0.012 | 1.01(1.00–1.03) | 0.026 |
| TyG-hsCRP ≤ 11.48 | 1(Ref.) | 1(Ref.) | ||
| TyG-hsCRP > 11.48 | 1.10(0.86–1.41) | 0.44 | 1.28(0.99–1.67) | 0.06 |
| TyG-CRP | 1.12(1.04–1.21) | 0.003 | 1.18(1.10–1.26) | 0.001 |
| TyG-CRP ≤ 9.40 | 1(Ref.) | 1(Ref.) | ||
| TyG-CRP > 9.40 | 1.18(0.92–1.51) | 0.202 | 1.70(1.23–2.37) | 0.001 |
| CTI | 1.10(1.00–1.24) | 0.018 | 1.33(1.08–1.66) | 0.008 |
| CTI ≤ 8.45 | 1(Ref.) | 1(Ref.) | ||
| CTI > 8.45 | 1.24(1.07–1.42) | 0.034 | 1.94(1.67–2.12) | 0.031 |
Adjusted model was fully adjusted for age, gender, BMI, systolic blood pressure, smoking status, hypertension, dyslipidemia, hemoglobin A1c, estimated glomerular filtration rate, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, use of antidiabetic agents, antihypertensive medication and lipid-lowering medication
TyG Triglyceride-glucose index, hsCRP High-sensitivity C-reactive protein, CRP C-reactive protein, CTI C-reactive protein–triglyceride glucose index, HR Hazard ratio, CI Confidence interval