Table 1.
Mediated Pathways Regulating Ferroptosis Between UKBPPP and SONFH
| UKBPPP | Ferroptosis | Disease | Mediated Effect (95% CI) | Mediated Proportion (95% CI) | p value |
|---|---|---|---|---|---|
| CCL17 | PRDX6 | SONFH | 0.203(0.081, 0.326) | 29.7%(11.8%, 47.6%) | 0.0011 |
| ZP3 | PRDX6 | SONFH | 0.0368(0.0213, 0.0523) | 22.7%(13.2%, 32.3%) | <0.001 |
| SPINK2 | PRDX6 | SONFH | 0.0469(0.0071, 0.0867) | 17.9%(2.71%, 33.1%) | 0.0209 |
| C7ORF50 | PRDX6 | SONFH | 0.0591(0.0164, 0.102) | 17.4%(4.84%, 30.1%) | 0.0067 |
| APOE | PRDX6 | SONFH | 0.0374(0.0116, 0.0632) | 15%(4.64%, 25.4%) | 0.0046 |
| ZP3 | FTMT | SONFH | 0.00229(0.000894, 0.00368) | 1.41%(0.552%, 2.27%) | 0.0013 |
| SPINK4 | FTMT | SONFH | 0.00306(0.000752, 0.00536) | 1.41%(0.346%, 2.47%) | 0.0093 |
Notes: Mediated effect and mediated proportion were calculated via two-step two-sample Mendelian randomization mediation analysis; p < 0.05 was considered statistically significant for the mediated effect.
Abbreviations: CI, confidence interval; UKBPPP, UK Biobank Proteomics Public Project; SONFH, steroid-induced osteonecrosis of the femoral head.