FIGURE 10.

The effects of melatonin (50 μM) and FMLP (50 nM) on NAD(P)H oscillations and oxidant release. (A) Although melatonin alone has no effect on NAD(P)H oscillations, when FMLP is added to the cells both the frequency and amplitude of the oscillations are increased. (B and C) The production of oxidants as detected by tetramethylrhosamine and EB formation are dramatically enhanced in the presence of melatonin and FMLP. (D) As noted in Fig. 7, FMLP increases the frequency of NAD(P)H oscillations. When melatonin is added, the amplitude increases. (E and F) The production of oxidants is enhanced by FMLP and further enhanced when melatonin is added.