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. 2003 Jan;84(1):69–81. doi: 10.1016/S0006-3495(03)74833-4

FIGURE 8.

FIGURE 8

The effect of DPI on NAD(P)H oscillations (a, c, and e) and superoxide release, as judged by the conversion of hydroethidine to ethidium bromide in the cellular environment, for polarized neutrophils. Although DPI had no effect on FMLP-stimulated NAD(P)H oscillations at low doses (0–10 mg/ml), doses in the range of 20–50 mg/ml DPI blocked acquisition of the ∼10 s period oscillation. Higher doses caused metabolic dynamics to disappear. Superoxide release paralleled the changes in NAD(P)H oscillations.