TABLE 1.
Structural data for TMs of CXCR4
| TM | TM center (x, y, z)/Å | Tilt angle of TM (θ)/degree | Bends within TM (χ)/degree |
|---|---|---|---|
| TM I | 12.34, −6.02, −3.28 | 20.96 | Almost straight |
| TM II | 10.16, 2.15, −2.04 | 26.78 | 23.06 (Pro92) |
| TM III | −1.76, 3.75, −0.75 | 27.89 | Almost straight |
| TM IV | −3.29, 13.12, −0.48 | 5.10 | 5.51 (Pro163); 13.48 (Pro170) |
| TM V | −11.87, 1.75, 0.78 | 36.00 | 23.72 (Pro211) |
| TM VI | −7.47, −8.39, 0.65 | 15.96 | 16.12 (Pro254) |
| TM VII | 2.65, −7.10, 2.41 | 5.89 | 6.72 (Pro299) |
| TM packing angles | ||||||
|---|---|---|---|---|---|---|
| TM1-TM2 | TM2-TM3 | TM3-TM4 | TM4-TM5 | TM5-TM6 | TM6-TM7 | TM7-TM1 |
| 156.98 | 159.55 | 157.17 | 149.25 | 160.15 | 161.57 | 164.52 |