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. 2003 Feb;84(2):897–909. doi: 10.1016/S0006-3495(03)74907-8

FIGURE 5.

FIGURE 5

The Hill coefficient at half activation, NH50, is plotted as a function of γ and Q at three levels of μ. The parameter γ is varied between 5 and 45 in increments of 2.5, whereas the parameter Q is varied between 1.25 and 3 in increments of 0.25. The contour lines show the isoclines for levels as labeled and increase with an increment of 2. Results for μ = 5 (A), 10 (B), and 15 (C). In general, NH50 is an increasing function of γ, μ, and Q. However, for the μ = 5 case, the dependence on Q is nonmonotonic, a feature investigated further in Fig. 6 (see text for details).