FIGURE 4.

Rb⁺ potentiates Kv4 currents. (A–C) Kv4.1, Kv4.2, and Kv4.3 currents evoked by repetitive step depolarizations to +50 mV from a holding potential of −100 mV. Inside-out patches were exposed to symmetric or bi-ionic conditions by switching the internal solution from 98 mM K⁺ (black traces) to 98 mM Rb⁺ (red traces). The pipette solution was 98 mM K⁺ (Materials and Methods). Scaled averaged outward currents are also shown (right panel; six to seven traces from each condition). (D) Box plots (Materials and Methods) comparing the fold change in the peak currents.