FIGURE 8.

Effect of deletion of the last 20 C-terminal amino acids on the activation by Gβ1/γ2 in the presence of PP2A. (A) Current trace recorded at −80 mV from an i.o. patch containing multiple GIRK1^ΔC20/GIRK4^wt channels (N = 3) at increasing concentrations of G_β1/γ2. (B) Comparisons of P_o at different concentrations of recombinant G_β1/γ2 for GIRK1^wt/GIRK4^wt and GIRK1^ΔC20/GIRK4^wt channels. ^***, The average P_o for patches containing GIRK1^wt/GIRK4^wt channels deviates significantly (p < 0.001) from patches containing channels of the GIRK1^ΔC20/GIRK4^wt composition.