TABLE 3.

Modal gating of phosphorylated/dephosphorylated channels

	10 nM Gβ1/γ2		100 nM Gβ1/γ2
	PKA-cs	PP2A	PKA-cs	PP2A
μ1 (Hz)	4.15 ± 0.37	3.11 ± 0.84	3.38‡ ± 0.42	4.26 ± 0.63
μ2 (Hz)	39.1 ± 6.7	13.4* ± 7.5	33.8 ± 4.0	20.0* ± 2.9
	0.58 ± 0.03	0.46 ± 0.17	0.74‡ ± 0.02	0.67 ± 0.06
(ms)	1.05 ± 0.02	0.95* ± 0.07	0.83 ± 0.01	0.79‡‡ ± 0.02
%silent segments	47.6 ± 5.3	94.6** ± 0.7	45.6 ± 3.1	56.1‡‡‡ ± 7.7

μ₁ and μ₂ designate the characteristic frequencies of slow and fast gating modes, the contribution of the fast gating mode to the segments at f_o = 0, the mean open time in all segments and %_{silent segments} the percentage of segments with no openings (see Methods section). Mean values ± standard error of mean value (SEM) are given for and %_{silent segments}, whereas the borders of the 95% confidence intervals are given for μ₁, μ₂, and . ^*, (^**): the difference in the mean value is statistically significant at the p < 0.05 (0.01) level, in comparisons between PKA-cs- and PP2A-treated patches, at the same internal concentration of G_β/γ. ^†††, the difference in the mean value is statistically significant at the p < 0.001 level, in comparisons between recordings obtained at 0 nM and 10 nM G_β/γ. ^‡‡, (^‡‡‡), the difference in the mean value is statistically significant at the p < 0.01 (0.001) level, in comparisons between recordings obtained at 10 nM and 100 nM G_β1/γ2.