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Open probability of IP3R at 10 μM IP3 and different cytosolic ATP concentrations: 0–12 μM (small squares), 500 μM (filled circles), 4.8 mM (large squares), and 9.5 mM (open circles). Data are from Mak et al. (1998, 1999). Curves represent calculated 
Actual Po differs by <5% (not shown). Dashed line corresponds to predicted Po at 1 mM [Ca2+]lum in the absence of ATP, assuming 
