TABLE 2.

Parameters of calcium handling model

dI	Dissociation constant for IP3 binding site	0.025 μM
dact	Dissociation constant for activating Ca2+ binding site	1.2 μM
dinh	Dissociation constant for inhibiting Ca2+ binding site	4.0 μM
vrel	Ca2+ release rate constant	1.0 s−1
vL	Leak rate constant	0.0005 s−1
Vmax	Maximum pump rate	0.12 μM/s
kP	Michaelis constant for the pump	0.4 μM
λ	Scaling parameter for density of pump and channels	30.0
β	Fraction of Ca2+ that is free	0.02
τ	Inhibition time constant	100 s
D0	Effective diffusion constant of Ca2+	40 μm2/s