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Average number of water clusters (corresponding to the 2–4 ns span). These clusters are constituted by loosely interacting water molecules. The criterion used was to group water molecules whose oxygen atoms are within 5 Å of any other water oxygen of the cluster. Clusters of only one element are not considered. The results for cutinase are represented by filled squares (upper part) whereas ubiquitin results are represented by filled triangles (lower part).
