TABLE 1.

Long-range interactions in the hydrophobic clusters of (α/β)₈ barrel proteins

PDB code	Residue number	Residue name	Hp	Nm	Nl	Nt	% long
1ALD	145	A	32.18	1	10	15	66.67
1BKS	174	T	28.67	2	10	16	62.50
1BTM	122	P	32.98	0	10	14	71.43
	208	Q	32.00	0	12	16	75.00
	229	G	29.63	0	10	14	71.43
1BYB	53	G	32.26	2	8	14	57.14
	103	I	29.00	1	10	15	66.67
	286	V	30.28	0	10	14	71.43
1CDG	19	Q	31.36	0	8	12	66.67
	74	I	28.51	1	8	13	61.54
	132	V	29.96	0	9	13	69.23
	223	I	27.61	3	7	14	50.00
	607	T	29.78	0	13	17	76.47
1CTN	166	Y	26.70	1	8	13	61.54
	250	G	29.59	2	9	15	60.00
1DHR	5	V	25.61	1	9	14	64.29
	74	A	25.08	0	11	15	73.33
	221	Q	24.93	0	10	14	71.43
1DIK	661	G	28.13	2	9	15	60.00
	737	T	32.37	0	12	16	75.00
1FCB	33	V	30.63	1	10	15	66.67
	277	L	27.69	1	8	13	61.54
1GHR	234	G	26.91	0	9	13	69.23
1GOX	249	I	26.91	1	11	16	68.75
1MLI	54	S	24.98	0	9	13	69.23
1MNS	33	V	28.48	0	11	15	73.33
1NAL	38	G	26.42	0	9	13	69.23
1NAR	221	V	28.34	2	8	14	57.14
1NIP	9	G	26.30	0	12	16	75.00
	33	V	27.06	0	11	15	73.33
	149	I	26.74	0	9	13	69.23
1PII	86	S	27.74	0	10	14	71.43
1PKY	219	S	31.10	0	12	16	75.00
	368	I	26.70	1	11	16	68.75
1SCU	45	V	29.93	0	10	14	71.43
	201	L	28.48	1	10	15	66.67
	211	C	26.88	1	9	14	64.29
	260	G	28.64	0	12	16	75.00
1TIM	124	A	30.93	0	11	15	73.33
	162	A	30.18	0	10	14	71.43
1TSY	231	A	28.49	4	5	13	38.46
1YPI	61	G	28.74	0	11	15	73.33
	162	A	30.20	0	10	14	71.43
2ACQ	156	I	28.67	1	11	16	68.75
	259	V	29.35	0	10	14	71.43
2CMD	115	G	27.04	0	8	12	66.67
2DRI	5	A	26.71	0	10	14	71.43
	61	L	30.05	1	9	14	64.29
	85	V	27.09	0	11	15	73.33
2TAA	12	Y	31.98	0	10	14	71.43
	60	I	26.90	0	8	12	66.67
	239	T	28.07	3	9	16	56.25
	291	T	32.91	0	12	16	75.00
	326	I	27.58	0	9	13	69.23
2TMD	23	R	31.26	1	10	15	66.67
	62	S	28.25	1	10	15	66.67
	104	L	29.88	0	11	15	73.33
	179	F	28.80	3	9	16	56.25
	283	V	27.98	4	7	15	46.67
	354	R	27.73	4	7	15	46.67
	483	V	29.47	1	9	14	64.29
3CBH	85	V	28.28	0	10	14	71.43
3ICD	28	P	35.26	0	10	14	71.43
	96	A	30.98	1	8	13	61.54
3MIN	147	A	30.78	0	12	16	75.00
	367	A	34.99	0	11	15	73.33
	391	H	27.56	0	10	14	71.43
4ENL	148	V	27.99	0	12	16	75.00
	244	G	27.96	0	10	14	71.43
	394	Q	29.40	0	13	17	76.47
5XIA	46	A	26.36	3	9	16	56.25
	180	P	26.24	0	13	17	76.47
	197	G	24.69	4	6	14	42.86
	212	L	27.40	0	13	17	76.47
8RUC	46	G	26.37	4	8	16	50.00
	316	D	27.05	0	13	17	76.47

No hydrophobic clusters were identified in the proteins 1RUS, 1MUC, and 2BNH. Hp, surrounding hydrophobicity; Nm, Nl, and Nt are, respectively, number of medium-range, long-range, and total (sum of short-, which is usually 4; medium-; and long-range) contacts (%long, Nl × 100.0/Nt).