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. 2003 Apr;84(4):2756–2767. doi: 10.1016/S0006-3495(03)75080-2

FIGURE 3.

FIGURE 3

Higher K+ effect on bipolar cell dynamics is mediated via a Cs+-sensitive hyperpolarization-activated inwardly rectifying conductance. (A) Voltage-current relation derived from recordings on a bipolar cell in high [K+]o (12 mM) without Cs+ (solution C, ▴) and with Cs+ (solution D, ▵). Cs+ suppresses inward rectification induced by high [K+]o. (B) Current responses to voltage-clamp steps in solution C (without Cs+). Note that the activation of the inward current is almost instantaneous. (C) Currents responses to the same set of voltage-clamp steps as in panel C, but recorded in solution D (with 10 mM Cs+), show suppression by Cs+ of the inwardly rectifying current. (D) The inward-rectifying current isolated by subtraction of currents in panel C from the corresponding currents in panel B. (E) I-V curve of the isolated current shows activation at <−50 mV.