FIGURE 6.

[Ca²⁺]_i responses of individual mouse β-cells to changing glucose from 0 to 10 mM. (A) Representative β-cell exhibiting mainly fast and stochastic [Ca²⁺]_i changes, including some near oscillations. (B) β-cell showing a mixture of fast and vestigial slow [Ca²⁺]_i changes. (C) β-cell showing very irregular [Ca²⁺]_i transients after glucose addition. Initial β-cell [Ca²⁺]_i changes often included initial decreases, a plateau phase (see text). All time bars represent 2 min.