TABLE 1.

UD parameters for the interaction of TTX and STX with the Nav1.4 sodium channel expressed in mammalian cells

	TTX
	CHO cells	Oocytes	STX
KT (nM)	26.6 ± 5.6	26 ± 4	1.8 ± 0.2
KM (nM)	7.7	8.6	0.74
Bi	0.63	0.62	0.76
kon (s−1 nM−1)	0.0029	0.0021	0.029
ν0 (s−1)	0.020	0.019	0.022

Data were obtained with an extracellular solution containing 100 mM Na⁺ and 2 mM Ca²⁺. Data obtained on Nav1.2 expressed in frog oocytes (Conti et al., 1996; Boccaccio et al., 1999) are presented for comparison.