. 2003 May;84(5):2999–3006. doi: 10.1016/S0006-3495(03)70026-5

TABLE 2.

Na⁺- and Ca²⁺-specific maximum UD effect, B_i,Na and B_i,Ca, for TTX and STX

	ν₀	K_Na (mM)	B_i,Na	ν_Na	K_Ca (mM)	B_i,Ca	ν_Ca
STX	0.022	34	0.56 ± 0.08	0.05	0.24 ± 0.01	0.88 ± 0.04	0.183
TTX	0.020	34	0.45 ± 0.06^*	0.036	0.16 ± 0.08^*	0.78 ± 0.04^*	0.091

For STX, parameters were obtained from the fit of Fig. 4 with Eq. 13. Sodium and calcium dissociation constants, K_Na and K_Ca, are also shown. K_Na was fixed 34 mM (Weigele and Barchi, 1978). The dissociation rate of the toxin from an ion-free channel, ν₀, and from channels occupied by Na⁺ or Ca²⁺, ν_Na and ν_Ca, were calculated from Eq. 11.

Data obtained on Nav1.2 expressed in frog oocytes (Conti et al., 1996; Boccaccio et al., 1999).