TABLE 2.

Activation parameters and thermodynamic parameters obtained from them for the interaction of PDC-109 with phospholipid/cholesterol membranes

	Lipid
Parameter	DMPC	DMPA	DMPG
ΔHa‡	50.11	11.32	16.48
ΔHd‡	43.03	41.64	36.74
ΔHo	7.08	−30.32	−20.26
ΔSa‡	36.36	−166.28	−136.39
ΔSd‡	−128.0	−121.06	−139.46
ΔSo	164.36	−45.22	3.07
ΔGa‡	39.45	60.07	56.46
ΔGd‡	80.55	77.13	77.62
ΔGo	−41.10	−17.06	−21.16

Units are: ΔH_a^‡, ΔH_d^‡, ΔH^o, ΔG_a^‡, ΔG_d^‡, and ΔG^o: kJ.mol⁻¹; ΔS_a^‡, ΔS_d^‡, and ΔS^o: J.mol⁻¹ K⁻¹. The standard of deviation of the parameters reported lie within 9% for ΔH and ΔG values whereas for ΔS values they are within 12% of the reported values (n = 4).