TABLE 4.

Partition coefficient data obtained from fluorescence experiments performed either at 25°C or at 45°C

	DPPC 25°C			DPPC 45°C
% of changes (Laurdan)	[Enf]H2O+air* (mM)	[Enf]H2O† mM	[Enf]/[Lip]ag‡	[Enf]H2O+air* (mM)	[Enf]H2O† mM	[Enf]/[Lip]ag‡
10	10	0.9§	0.8	2.2	0.1§	0.02
20	13	1.2	1.1	3.6	0.3§	0.1
30	16	1.45	1.2	5.3	0.5§	0.2
40	18	1.6	1.3	7.3	0.7	0.3
50	20	1.8	1.4	9.6	0.9	0.4
60	22	2.0	1.5	12.3	1.1	0.6
70	25	2.3	1.6	15.9	1.4	0.7
80	28	2.5	1.7	20.9	1.9	1.0
90	32	2.9	1.9	29.3	2.7	1.3

^*[Enf]_H2O+air is the concentration of enflurane that is not in interaction with the lipids in the lamellar phases.

^†[Enf]_H2O was estimated from the [Enf](_air+H2O) assuming that the partition coefficient of enflurane between air and water is ∼10 and that the air and the water volumes in the cuvette were similar.

^‡[Enf]/[Lip]_ag is the enflurane-to-lipid concentration ratio within the lamellar phases. These values are determined from the origin and the slope of the linear relationships plotted on Figs. 9 (25°C) and 10 (45°C), respectively.

^§The [Enf]_H2O in bold are those that fall within the clinical concentration range.