FIG. 1.

Short-term protection of V. vulnificus MLT403-infected mice by phage CK-2. Iron-dextran-treated mice were inoculated s.c. with 10⁶ CFU of V. vulnificus MLT403. Mice were immediately injected i.v. with BSG (C) or phage CK-2 (CK-2), and samples were harvested 14 to 18 h postinfection. Data are means and standard deviations for log CFU per gram of skin lesion (Lesion CFU), log CFU per gram of liver (Liver CFU), and rectal temperature (Temp). The temperature was divided by 10 and then plotted to fit the same scale as the other values. For lesion score (Lesion), the mean is shown. All groups contained five animals. An asterisk indicates that the difference between control and phage-treated groups was statistically significant, as determined by the Student t test, as follows: lesion CFU, P = 0.016; liver CFU, P = 1.6 × 10⁻⁴; temperature, P = 7.6 × 10⁻⁸.