FIG. 3.

Gross pathologic features of V. vulnificus MO6-24/0-infected mice treated with phages 153A-5 and 153A-7. Dorsal views of gross pathologic features of s.c. lesions caused by V. vulnificus MO6-24/0 in iron-dextran-treated mice from the experiment shown in Fig. 2 are presented.(A) Iron-dextran-treated mouse that was not infected. (B to E) Mice injected i.p. with iron dextran and then immediately injected s.c. in the lower right dorsal quadrant with 417 CFU of MO6-24/0. Immediately after s.c. infection, mice received an i.v. injection of sterile BSG (B), 10⁸ PFU of phage 153A-7 (C and D), or 10⁸ PFU of phage 153A-5 (E). Mice in panels B, C, and E were euthanized at between 14 and 20 h later, and the skin was peeled back from the head to the tail to reveal s.c. tissues. The mouse in panel D was euthanized 6 days after s.c. infection. Panels B and E reveal large, edematous, hemorrhagic lesions that have lesion scores of 3. Mice in panels C and D had lesion scores of 2.