FIG. 6.

Delay of phage 153A-5 treatment of V. vulnificus MO6-24/0-infected mice. Iron-dextran-treated mice were inoculated s.c. with 1,070 CFU of V. vulnificus MO6-24/0. Mice were injected i.v. with BSG (control) (C) immediately or with 10⁸ PFU of phage 153A-5 immediately (0), 3 h later (3), or 6 h later (6). Samples were harvested 14 h after s.c. inoculation. Data are means and standard deviations for log CFU per gram of skin lesion (Lesion CFU), log CFU per gram of liver lesion (Liver CFU), and rectal temperature (Temp). For lesion score (Lesion), the mean is shown. All groups contained five animals. Single asterisks indicate that values for the control group were significantly different from those for all of the phage-treated groups (10⁻⁹ < P < 0.013). Double asterisks indicate that the 0-h treatment delay group was significantly protected compared with the 3- and 6-h treatment delay groups (6 × 10⁻⁶ < P < 0.0035).