TABLE 2.

Model variables

Variable	Description
S	Ligand concentration
C	Ligand-receptor complex surface concentration
	Total number of complex molecules over the cell
Pi,j	Number of active protease molecules per cell
t	Time
X,Y	Coordinates in the plane of the epithelium
Z	Transverse coordinate
	Dimensionless ligand concentration
	Dimensionless ligand-receptor complex surface concentration
	Dimensionless total number of complex molecules over the cell ij
	Dimensionless number of active protease molecules per cell
	Dimensionless time
	Dimensionless spatial variable