ERVs	Endogenous Retroviruses
PRRs	Pattern Recognition Receptors
cGAS	Cyclic GMP-AMP Synthase
RIG-I	Retinoic Acid-Inducible Gene I
TLRs	Toll-Like Receptors
LTR	Long Terminal Repeat
HERV-K (HML-2)	Human Endogenous Retrovirus K (Human MMTV-Like 2)
Gag	Group-Specific Antigen
Pro	Protease
Pol	Polymerase
Env	Envelope
RT	Reverse Transcriptase
INT	Integrase
TSS	Transcription Start Site
ORF	Open Reading Frame
DNMTs	DNA Methyltransferases
SAM	S-adenosyl Methionine
5mC	5-methylcytosine
TFBS	Transcription Factor Binding Site
MBDs	Methyl-Binding Domains
HNC	Head and Neck Cancer
DNMTi	DNMT Inhibitor
CICs	Colorectal Cancer-Initiating Cells
dsRNA	Double-Stranded RNA
ssRNA	Single-Stranded RNA
DHS	DNase I Hypersensitivity Sites
TF	Transcription Factor
ChIP-seq	Chromatin Immunoprecipitation sequencing
STAT1	Signal Transducer and Activator of Transcription 1
IRF1	Interferon Regulatory Factor 1
ISGs	Interferon-Stimulated Genes
MER41	Medium-Reiteration-frequency-family 41
CRISPR-Cas9	Clustered Regularly Interspaced Short Palindromic Repeats—CRISPR Associated Protein 9
AIM2	Absent in Melanoma 2
IFN-γ	Interferon Gamma
mRNA	Messenger RNA
PBS	Primer Binding Site
PAMPs	Pathogen-Associated Molecular Patterns
MyD88	Myeloid Differentiation Primary Response 88
TRIF	TIR-domain-containing adapter-inducing interferon-β
IRF3/7	Interferon Regulatory Factor 3/7
NF-κB	Nuclear Factor Kappa B
IFN-I	Type I Interferon
IL-6	Interleukin 6
MSRV	Multiple Sclerosis-Associated Retrovirus
Th1	T Helper 1
STING	Stimulator of Interferon Genes
GTP	Guanosine Triphosphate
ATP	Adenosine Triphosphate
cGAMP	cyclic GMP-AMP
TBK1	TANK-Binding Kinase 1
IKKϵ	Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon
MDA5	Melanoma Differentiation-Associated protein 5
MAVS	Mitochondrial Antiviral-Signaling Protein
CARDs	Caspase Activation and Recruitment Domains
SARS-CoV-2	Severe Acute Respiratory Syndrome Coronavirus 2
PKR	Protein Kinase R
TREX1	Three Prime Repair Exonuclease 1
SETDB1	SET Domain Bifurcated Histone Lysine Methyltransferase 1
HDAC	Histone Deacetylase
EZH2	Enhancer of Zeste Homolog 2
SASP	Senescence-Associated Secretory Phenotype
CTD	C-Terminal Domain
MAMs	Mitochondrial-Associated Membranes
LGP2	Laboratory of Genetics and Physiology 2
SNPs	Single Nucleotide Polymorphisms
IL-10	Interleukin 10
TGF-β	Transforming Growth Factor Beta
Tregs	Regulatory T Cells
miRNAs	MicroRNAs
SLE	Systemic Lupus Erythematosus
EREs	Endogenous Retroviral Elements
ADAR1	Adenosine Deaminase Acting on RNA 1
SOCS	Suppressor of Cytokine Signaling
ISG	Interferon-Stimulated Gene
DCs	Dendritic Cells
KRAB-ZFPs	Krueppel-Associated Box Domain-Zinc Finger Proteins
KAP1	KRAB-Associated Protein 1
H3K9me3	Histone H3 Lysine 9 Trimethylation
SAMHD1	SAM and HD Domain-Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1
dNTPs	Deoxynucleotide Triphosphates
MHC	Major Histocompatibility Complex
APOBEC3	Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide-like 3
NLRP3	NOD-, LRR- and Pyrin Domain-Containing Protein 3
IL-1β	Interleukin 1 Beta
IL-18	Interleukin 18
JAK	Janus Kinase
TRIM	Tripartite Motif
CLL-1	C-Type Lectin-Like Molecule-1
RNA-seq	RNA Sequencing
TET1	Ten-Eleven Translocation Methylcytosine Dioxygenase 1
CTCF	CCCTC-Binding Factor
EF-hand	Helix-Loop-Helix Structural Domain
ASC	Apoptosis-Associated Speck-like Protein Containing a CARD
NEK7	NIMA-Related Kinase 7
DAMP	Damage-Associated Molecular Patterns
SARM1	Sterile Alpha and TIR Motif-containing protein 1
RLR	RIG-I-Like Receptor