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Water molecules before the barrier serve as hydrogen bond bridges between the two core sheets. In Fig. 7 a, a water molecule bridges Leu-16 (RT loop) and Tyr-47 (β4). In Fig. 7 b, postdesolvation, Leu-16 and Tyr-47 form a direct hydrogen bond, closing the hydrophobic core through the RT loop-β4 interaction.
