Production of IL-12 and TNF-α by macrophages upon uptake of M. tuberculosis. Lab, laboratory conditions; Anaero, anaerobiosis; Hyperos, hyperosmolarity; pH 6, acidic pH; control, uninfected macrophage control; *, P < 0.05 compared to laboratory conditions; **, production at 24 h. Numbers represent the means ± standard deviations of four different experiments.