Information content, I[di,j] by sequence separation with bounded distance detection. Mean information content as a function of sequence separation for single distance constraints is plotted for N = 15 with given distance detection limits, u. Distances are encoded as di,j for di,j ≤ u and as equal to u for di,j > u. ○: 1 unit; □: 1.42 units; ⋄: 2 units; ▵: 6 units; ◃: No limit.