Table 3.
Adjusted Cox model for effect of nonconventional versus conventional lesions on the development of colorectal adenocarcinoma.
| Effect | Location level | |
|---|---|---|
| HR (95% CI) | P-value | |
| Cumulative conventional lesion counta | 2.18 (1.34, 3.52) | .002 |
| Cumulative nonconventional lesion counta | 2.28b (1.59, 3.26) | <.001 |
| Age (per 5 years) | 1.11 (1.01, 1.23) | .04 |
| Female | 0.89 (0.45, 1.73) | .72 |
| Year of first surveillance endoscopic procedure | 1.14 (1.03, 1.26) | .01 |
| Surveillance endoscopic procedure prior to 2007 | 0.75 (0.33, 1.70) | .48 |
| IBD duration, years | 1.00 (0.99, 1.02) | .87 |
| PSC | 3.62 (1.23, 10.67) | .02 |
| Cholangiocarcinoma | 1.89 (0.21, 10.34) | .46 |
| Liver transplant | 0.97 (0.21, 4.51) | .97 |
| History of invisible low/high-grade dysplasia | 32.8 (14.3, 75.3) | <.001 |
| History of other invisible dysplasia | 2.20 (0.95, 5.11) | .07 |
Abbreviations: CI, confidence interval; HR, hazard ratio; IBD, inflammatory bowel disease; PSC, primary sclerosing cholangitis.
aSquare-root transformation was used.
bThe effect of nonconventional lesions versus conventional lesions was HR 1.05 (95% CI 0.57, 1.92; P = .89).