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. 2026 Feb 21;17:58. doi: 10.1186/s13293-026-00860-6

Table 3.

Full outputs for the linear models stratified by sex examining APOE genotype differences in cognitive outcomes

DSST Initial DSST Slope 3MS Initial 3MS Slope
Female
 APOE ε3 (Reference)
 APOE ε2 β = 1.14; p = 0.117 β = 0.04; p = 0.230 β = 0.38; p = 0.381 β = 0.15; p = 0.002
 APOE ε4 β=-0.50; p = 0.366 β=-0.10; p = < 0.001 β=-0.98; p = 0.003 β=-0.13; p = < 0.001
Male
 APOE ε3 (Reference)
 APOE ε2 β=-0.32; p = 0.645 β = 0.04; p = 0.152 β = 0.21; p = 0.615 β = 0.06; p = 0.215
 APOE ε4 β=-1.13; p = 0.045 β=-0.07; p = 0.005 β=-1.66; p = < 0.001 β=-0.22; p = < 0.001
Race (Reference: Black) β = 9.03; p = < 0.001 β=-0.00; p = 0.776 β = 4.54; p = < 0.001 β = 0.22; p = < 0.001
Site (Reference: Memphis) β = 3.38; p = < 0.001 β = 0.02; p = 0.105 β = 1.43; p = < 0.001 β = 0.29; p = < 0.001
Age β=-0.83; p = < 0.001 β=-0.01; p = < 0.001 β=-0.32; p = < 0.001 β=-0.04; p = < 0.001
Education
 Completed High School (Reference)
 Did not Complete High School β=-7.68; p = < 0.001 β = 0.01; p = 0.543 β=-4.20; p = < 0.001 β=-0.16; p = < 0.001
 Greater than High School β = 4.46; p = < 0.001 β = 0.02; p = 0.176 β = 2.56; p = < 0.001 β = 0.14; p = < 0.001
Health Score Composite β=-1.55; p = < 0.001 β=-0.02; p = 0.007 β=-0.35; p = 0.005 β=-0.03; p = 0.011

Significant associations are presented in boldface. Digit Symbol Substitution Test (DSST), Modified Mini-Mental Status Examination (3MS), and Body Mass Index (BMI)