TABLE 2.
Immune differences between patients with and without BCG vaccine scarring and with M. tuberculosis bloodstream infections
| Parameter | Median value (range) for participants with BCG scarring:
|
P | |
|---|---|---|---|
| Present (n = 6) | Absent (n = 4) | ||
| % of cells making IL-4 | |||
| Lymphocytes (U)a | 5.0 (2.2-15.5) | 2.1 (1.8-4.3) | 0.042 |
| T cells (S) | 2.9 (1.4-7.2) | 0.9 (0.4-1.7) | 0.040 |
| B cells (U) | 2.7 (1.4-12.0) | 1.0 (0.7-1.3) | 0.014 |
| % of NT cellsb making both TNF-α and IFN-γ (U) | 0.5 (0.1-2.4) | 0 (0-0.3) | 0.030 |
| % of T cells making IL-4/% making IL-8 (S) | 3.0 (2.4-12.0) | 0.7 (0-1.2) | 0.014 |
| % of T cells making IL-10/% making IL-8 (S) | 1.6 (0.8-9.9) | 0.7 (0-0.9) | 0.043 |
| % of cells expressing CD45RO | |||
| T cells | 75.8 (47.7-89.6) | 47.5 (36.4-58.1) | 0.043 |
| CD8− T cells | 48.5 (30.1-50.9) | 26.5 (24.5-35.1) | 0.025 |
| CD8+ T cells | 74.7 (51.8-96.0) | 50.7 (41.1-58.3) | 0.043 |
| % of cells expressing CD45RAc | |||
| T cells | 27.9 (11.8-49.5) | 50.7 (40.8-65.5) | 0.043 |
| CD8+ T cells | 23.7 (9.2-38.8) | 45.6 (32.4-64.8) | 0.043 |
| % of cells expressing CD38 | |||
| T cells | 88.9 (77.7-92.9) | 63.6 (41.4-79.6) | 0.025 |
| CD8+ T cells | 92.2 (89.5-95.8) | 59.7 (4.5-83.8) | 0.014 |
| % of CD8+ T cells expressing both CD38 and HLA-DR | 28.5 (11.4-61.0) | 9.2 (1.3-12.3) | 0.025 |
a
U, without ex vivo stimulation; S, with ex vivo PMA and ionomycin stimulation.
b
Natural T (NT) cells defined as CD3+ CD16/56+ lymphocytes.
c
Differences in the proportions of CD8-negative T cells expressing CD45RA did not reach significance (medians: with scarring, 45.8%; without scarring, 60.3%; P = 0.070).