Table 1.
Clinical characteristics of 48 patients with ASyS
| Variable | Total (n = 48) |
Male (n = 13) |
Female (n = 35) |
P value Male vs. female |
|---|---|---|---|---|
|
Age at onset (years), median (IQR) |
54.0 (46.0–67.0) |
49.0 (46.0–64.0) |
54.0 (47.5–69.0) |
0.547 |
| Clinical phenotype | ||||
| DM | 20 (42) | 2 (15) | 18 (51) | 0.046 |
| CADM | 16 (33) | 8 (62) | 8 (23) | 0.018 |
| PM | 1 (2) | 0 (0) | 1 (3) | 1.000 |
| IPAF | 11 (23) | 3 (23) | 8 (23) | 1.000 |
| The type of autoantibody | ||||
| Anti-Jo1 antibody positive | 17 (35) | 3 (23) | 14 (40) | 0.330 |
| Anti-SS-A antibody positive | 14 (29) | 2 (15) | 12 (34) | 0.292 |
| Fever | 9 (19) | 1 (8) | 6 (17) | 0.687 |
| ILD | 47 (98) | 13 (100) | 34 (97) | 1.000 |
| Raynaud’s phenomenon | 6 (13) | 0 (0) | 6 (17) | 0.171 |
| Malignancy | 6 (13) | 1 (8) | 5 (14) | 1.000 |
| Breast cancer | 2 (4) | 0 (0) | 2 (6) | |
| Lung cancer | 1 (2) | 0 (0) | 1 (3) | |
| Renal cancer | 1 (2) | 0 (0) | 1 (3) | |
| Skin cancer | 1 (2) | 0 (0) | 1 (3) | |
| Prostate cancer | 1 (2) | 1 (8) | 0 (0) | |
| Muscle involvement, n (%) | ||||
| Muscle weakness | 25 (52) | 7 (54) | 18 (51) | 1.000 |
| Dysphagia | 0 (0) | 0 (0) | 0 (0) | 1.000 |
| Skin involvement, n (%) | ||||
| Gottron’s sign | 35 (73) | 10 (77) | 25 (71) | 1.000 |
| Mechanic’s hands | 31 (65) | 8 (62) | 23 (66) | 1.000 |
| Nailfold erythema | 19 (40) | 5 (38) | 14 (40) | 1.000 |
| Nailfold capillary abnormalities | 15 (31) | 1 (8) | 12 (34) | 0.721 |
| Shawl sign | 10 (21) | 1 (8) | 9 (26) | 0.248 |
| Heliotrope rash | 9 (19) | 5 (38) | 4 (11) | 0.048 |
| Gottron’s papules | 8 (17) | 4 (31) | 4 (11) | 0.187 |
| V-neck sign | 6 (13) | 1 (8) | 5 (14) | 1.000 |
| Auricular erythema | 4 (8) | 1 (8) | 3 (9) | 1.000 |
| Clubbed finger | 3 (6) | 2 (15) | 1 (3) | 0.174 |
| Flagellate erythema | 2 (4) | 2 (15) | 0 (0) | 0.069 |
| Chilblains | 2 (4) | 0 (0) | 2 (6) | 1.000 |
| Palmar papule | 1 (1) | 0 (0) | 1 (3) | 1.000 |
| Poikiloderma | 1 (1) | 0 (0) | 1 (3) | 1.000 |
| Outcome | ||||
| Dead | 3 (6) | 0 (0) | 3 (9) | 0.553 |
IQR Interquartile range, ILD Interstitial lung disease, ASyS Antisynthetase syndrome, DM Dermatomyositis, ADM Amyopathic dermatomyositis, PM Polymyositis, IPAF Interstitial pneumonia with autoimmune feature