Table 3.
Comparison of ASyS clinical manifestations between our cohort and Asian cohorts
| Variable | Japan | China | |||
|---|---|---|---|---|---|
| Our cohort | Hamaguchi et al. [22] |
Yamamoto et al. [5] |
Zhang et al. [17] |
Shi et al. [23] |
|
| Number of cases, n | 48 | 165 | 125 | 119 | 124 |
| Female, n (%) | 35 (73) | 130 (79) | 92 (74) | 88 (74) | 94 (76) |
|
Age at onset (years), mean (range) |
56.5 (27–87) |
53 (18–79) |
57.5 (45–68) |
54 [50–60] |
50.4 (mean) |
| Anti-Jo1 antibody positive, n (%) | 17 (35) | 59 (36) | 34 (27) | 59 (50) | 62 (50) |
| ILD, n (%) | 47 (98) | 155 (94) | 125 (100) | 111 (93) | 117 (94) |
| Raynaud’s phenomenon, n (%) | 6 (13) | 40 (24) | 17 (23) | 18 (15) | 12 (10) |
| Malignancy, n (%) | 6 (13) | 19 (12) | 5 (4) | - | 8 (7) |
| Muscle weakness, n (%) | 25 (52) | 95 (58) | 82 (66) | 53 (45) | 79 (64) |
| Skin involvement, n (%) | |||||
| Gottron’s sign (hand) | 23 (48) | 63 (38) | - | - | - |
| Gottron’s sign (elbow and/or knee) | 25 (52) | 51 (31) | - | - | - |
| Gottron’s sign | 35 (73) | - | 23 (18) | - | - |
| Gottron’s papules | 8 (17) | - | 50 (40) | 20 (17) | 55 (44) |
| Heliotrope rash | 9 (19) | 26 (16) | 33 (17) | 9 (19) | 0.485 |
| Mechanic’s hands | 31 (65) | 67 (41) | 64 (50) | 67 (56) | 57 (46) |
| Shawl sign | 10 (21) | - | - | 7 (6) | - |
| V-neck sign | 6 (13) | - | - | 10 (8) | - |
ILD Interstitial lung disease