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AFM micrographs of the fusion pore or porosome, as it appears at the cell surface and at the cytosolic side. (a) A pit with four fusion pores within, found at the apical surface in a live pancreatic acinar cell. (b) AFM micrograph of isolated plasma membrane preparation reveals the cytosolic end of a pit with inverted cup-shaped structures, the fusion pores. (c) A single fusion pore at the cell surface, and (d) as it appears at the cytosolic side of the cell membrane.
