FIG. 1.

PAC are a poor source of APC for C. neoformans, while TAC are a potent source of APC. PBMC, T cells (2 × 10⁵/well), T cells plus irradiated PBMC, T cells plus PAC (10⁵/well), or T cells plus TAC (10⁵/well) were stimulated with killed C. neoformans strain 67 (A), and T cells, T cells plus irradiated PBMC, or T cells plus PAC were stimulated with concanavalin A (Con A) (B). [³H]TdR incorporation was determined 7 days later if the cells were stimulated with C. neoformans and 3 days later if the cells were stimulated with concanavalin A. The experiment was repeated three times with similar results. ∗, P < 0.05 compared to the corresponding unstimulated group.