FIGURE 5.

Activation and inactivation properties of the ionic conductances in the model. For each conductance, steady-state activation and inactivation are plotted against voltage at the left; the time constants of activation and inactivation are plotted in the middle; and a simulation of representative voltage-clamp currents are plotted on the right. In the third panel, the simulation is represented by the solid line and the averaged experimental data by the dotted line. (A) I_Na,T (solid lines) and I_Na,P (dotted line). (B) The two components of I_K. The fast component is shown with solid lines and the slow component with dashed lines. The voltage-clamp simulation includes both components together. There is a small, residual sodium current that obscures the initial few milliseconds in the experimental traces.