FIGURE 10.

Flow chart for simulation mapping back into our original model. Here we basically have free monomers (fMs), attached monomers that are not yet stably misfolded (aM), and monomers that have stably misfolded and aggregated (H). We have some choice of a parameter, Q_bc = m. This model will capture the features of our original model for m between 3 and 6, and the simulation will proceed in exactly the same way. We compute N_bc, the bond coordination number, with N_bc = n_fM + n_aM + (m − 1) × n_H, where the n is the number of neighboring fMs, and so on. N_hc, the “hardening” or aggregating coordination number, is given by N_hc = n_fM + n_aM + n_H. We refer to Q_bc as the bonding critical coordination number and Q_hc as the “hardening” critical coordination number.