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. 2003 Oct;85(4):2299–2310. doi: 10.1016/s0006-3495(03)74654-2

FIGURE 6.

FIGURE 6

Interactions of D762K and E765K with R1A, K11A, R13A, K16A, and R19A. (A) Bar graphs summarizing the half-blocking concentrations (IC50) for block of WT, D762K, and E765K channels by WT μ-CTX and the point-mutated derivatives K11A, R13A, and K16A. (B) Estimated ΔΔGs of D762K and E765K with K11A, R13A, and K16A. Our previous results with R1A and R19A (Li et al., 2001a) are also shown for comparison. Both D762 and E765 interact most strongly with R13, K16, and R19 but relatively weakly with R1 and K11. The interaction of D762K was strongest with R13 and decreased progressively toward K16 and R19; those of E765 with R13, K16, and R19 were of similar magnitude.