TABLE 2.
Amphotericin B concentration threshold as defined in the text for DMPC, egg lecithin, and the bacterial lipids formed at the tip of a micropipette (<1 μm2) in the presence or absence of sterols and different temperatures
AmB concentration threshold (M)
|
|||||
---|---|---|---|---|---|
DMPC*
|
Egg lecithin
|
E. coli IOM
|
|||
Sterol | 30°C | 25°C | 15°C | 25°C | 15°C |
0 mol % | 10−4 | 10−4 | 10−5 | >10−4 | 10−5 |
Chol 30 mol % | 10−7 | 10−6 | 10−5 | ||
Erg 30 mol % | <10−7 |
The membrane potential and buffer used are those quoted in Table 1. Chol, cholesterol; Erg, ergosterol.